California seeks admission to the Union as a free state.
Second major cholera epidemic.
Jewish congregation established in San Francisco.
Astor Place theater riot leaves twenty dead.
Sugar production in Louisiana reaches its peak.
Period of high cotton prices begins.
California gold rush.
Elizabeth Blackwell becomes first female physician in the U.S.
Bureau of Indian Affairs is moved to the newly created Department of the Interior.Harriet Tubman escapes slavery; begins working with Underground Railroad.