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Bio-Organic Chemistry First
Learn More (14 Questions Answered)

What Do Other People Do?

When you teach Organic First, lots of changes follow in your curriculum. Not every school that teaches Organic First makes the same choices. Below are some questions that come up when you consider the switch to Organic First as well as answers by three schools that operate this way. The three schools are Bucknell University, University of Michigan, and New College.

  1. Is there any prescreening of who can take the course? What happens to students who do not make the cut?
  2. Are Chemistry majors treated any differently than non-majors?
  3. What book do you use?
  4. What do you need to add/expand due to the fact that your class is composed of first-year students who did not just take a general chemistry course?
  5. What do you leave out due to the fact that your class is composed of first-year students who did not just take a general chemistry course?
  6. Do you add things not normally covered in sophomore organic courses?
  7. What are your first-year labs?
  8. What happens sophomore year? What courses are offered? What labs are used? Are majors treated any differently from non-majors?
  9. What happens junior year? Is Physical Chemistry any different from what it used to be?
  10. If there were any holes in the organic coverage, when do they get filled?
  11. How do you handle transfers in and out?
  12. Do any clients have any problems with this approach (geologists, engineers, etc.)?
  13. Med/Grad school acceptance rates (before/after)
  14. Are there any objective measures of this program's success?
  1. Is there any prescreening of who can take the course? What happens to students who do not make the cut?

    Bucknell: No, but high school chemistry is expected.

    New College: Yes, but we have yet to find a good test that correlates well with performance in the course. Work habits are more important than preparation. We have a course second semester, "Chemistry and Society," that uses the ACS text for general interest students and students with no high school chemistry background.

    University of Michigan:
    SHORT ANSWER: Incoming students get advice based on the results of an examination. Those above a certain threshold are advised to start in the organic base course, "Structures and Reactivity", while those who fall below this are advised to start in a one-term "Principles" course. S/R began in 1989.

    LONG ANSWER: Our average first-year student has an 1100 combined SAT score and a 28 ACT. About 2500 incoming first-year students take a 40 question multiple-choice general chemistry test. Those who score at the 70th percentile or above are advised to begin in "Structures and Reactivity" (S/R). About 600 students do this. Around 1300 of the remaining students take a one-term "General Principles" course; the rest elect chemistry later. The 600 first-year students who begin in S/R are joined by about 400—500 additional students–primarily sophomores–who either waited to take chemistry or who came through the "Principles" course. The placement advice does not line up with the populations in the two possible first-term courses. Most of the students (65%) in the "Principles" course are engineering majors who need their terminal course; they often do well on the placement exam, but their programs ask them to take the "Principles" course anyway. The S/R students are mainly science majors and pre-med/vet/dent students. About 10% of the class is made up of grad students from other disciplines and undergraduates who take S/R for a science elective course.


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  1. Are Chemistry majors treated any differently than non-majors?

    Bucknell: All chem, biochem, and BS bio majors are expected to take two semesters of organic in the first year. BA bio majors are encouraged to do the same but some defer organic until the second year. Because of other curriculum constraints, the chem engineers cannot take organic until the second year.

    New College: None

    University of Michigan:
    SHORT ANSWER: No, although science-motivated students have a 3 hr/wk supplemental instruction option if they want to explore the subject at a deeper level.

    LONG ANSWER: No. There is a supplemental instruction program that science-motivated students may elect, and in doing so earn Honors credit. The Structured Study Group (SSG) program employs undergraduate juniors and seniors who are interested in future faculty development as facilitators for these sessions. In the second term of "Structure and Reactivity" there is a separate section of the course offered to about 100 self-selected, science-motivated students. All of the students in this section are enrolled in SSGs.


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  1. What book do you use?

    Bucknell: McMurry. We have found that the level is excellent for a first-year course. Other texts that the faculty liked better were deemed to be written at too high a level for a first-year course.

    New College: Ege "Organic Chemistry" 4th ed. and also Scudder "Electron Flow in Organic Chemistry" as a supplement

    University of Michigan: "Organic Chemistry" 4th ed., by Seyhan N. Ege


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  1. What do you need to add/expand due to the fact that your class is composed of first-year students who did not just take a general chem course?

    Bucknell: We spend more time on the introductory chapters and topics: bonding, Lewis structures, electronegativity, resonance, Bronsted acid-base, etc. But even though this material is hit hard, the amount of time devoted is not excessive, perhaps three weeks.

    New College: More bonding theory, I bring in a long spring to show standing waves. VSEPR with balloons along with hybridization. Extensive acid/base theory and pKa chart use. Basic thermodynamics and kinetics. Unique to my course: hard soft acid base theory and some PMO theory (since we are an honors college).

    University of Michigan: Nothing. In the first term we do Ch. 1—9 and 12. In the second term we do Ch. 13—25.


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  1. What do you leave out due to the fact that your class is composed of first-year students who did not just take a general chem course?

    Bucknell: We have not covered mass spectroscopy nor UV/vis. We do very little MO theory. We rarely get to spend time on the chapters at the back of the book: amines and biomolecules. Also, some topics are de-emphasized such as radical halogenations and aromaticity. In addition, in the second semester, we do all of carbonyl chemistry (McMurry, Ch. 19—23) before doing electrophilic aromatic substitution (McMurry, Ch. 15—16). This results in less time spent on EAS.

    New College: Some second semester special topics.

    University of Michigan: Nothing. Although if you study this text, you will see that synthesis is not emphasized as an organizer.


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  1. Do you add things not normally covered in sophomore organic courses?

    Bucknell: No.

    University of Michigan: Not compared with our own pre-1989 sophomore courses. The special science-oriented section of the second term courses are a different story, though. There is lots of student-generated work, and we include pericyclics, physical organic, ethics, bio-organic chemistry, and a great deal more spectroscopic identification.


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  1. What are your first-year labs?

    Bucknell: All organic students take one four-hour lab per week. The lab manual is written and produced in-house. We begin the first semester with a series of "techniques" labs: melting point, TLC, extractive techniques, recrystallization, identification of unknowns. Then we do two isolation experiments: caffeine from tea and essential oils from spices (steam distillation and GC). We do two synthetic experiments (stilbene epoxide and diphenylacetylene). The last experiment is a resolution of enantiomers by fractional crystallization.

    In the second semester, we use IR, GC, and NMR techniques more. Most of the experiments are synthetic, including a Grignard reaction to make triphenylmethanol, preparation of 4-nitroaniline by nitration of acetanilide and hydrolysis, synthesis of acetate esters by Fisher esterification, oxidation of borneol and reduction of camphor, etc.

    New College: Our first-semester lab is more isolations and identifications, similar to Michigan's labs. Second semester is a standard organic lab doing microscale organic reactions.

    University of Michigan: The first lab course has a more physical organic and analytical flavor to it, while the second-term lab course is where students are introduced to synthesis and characterization.


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  1. What happens sophomore year? What courses are offered? What labs are used? Are majors treated any differently from non-majors?

    Bucknell: Chem, biochem, and BS bio majors take "Inorganic I" in the fall and "Analyt I" in the spring. Chem engineers take "Inorganic I" in the spring of their first year and "Analyt I" in the spring on their second year, concurrently with the second semester of organic. Both "Inorganic I" and "Analyt I" have a weekly lab.

    New College: Our first semester course, "Chemistry Principles," covers the remainder of the General Chemistry course and starts the intro to Inorganic, which follows second semester. Both have labs.

    University of Michigan: First-term sophomores, including majors and pre-med/vet/dents, take an introductory P-chem course. First-term sophomore chemistry, biochemistry, and cell-molecular bio students take two other courses: "Analytical Lecture," "Analytical Lab." In the second term, the science majors take a first term Inorganic chemistry course, while the majors also take an advanced laboratory that combined organic and inorganic chemistry.


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  1. What happens junior year? Is Physical Chemistry any different from what it used to be?

    Bucknell: Chem majors take two semesters of P-chem in the third year. Biochem majors may chose one semester of either of the regular P-chem courses or they may opt for a one-semester course, Bio P-chem; most choose the latter.

    New College: No change.

    University of Michigan: First term: "Quantum and Computational Chemistry." Second term: "Thermo and Kinetics." Some students take Instrumental at this point.


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  1. If there were any holes in the organic coverage, when do they get filled?

    Bucknell: No major holes. Two advanced courses are offered as electives: "Mechanistic Organic" (a physical organic course) and "Advanced Organic" (a synthesis course).

    New College: In the third semester, with a Chem principles course. We have basically combined Organic and General Chem into a three-semester sequence, with organic first.

    University of Michigan: There is an elective "Intermediate Organic" course that some sophomores have taken, but is mostly taken by juniors.


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  1. How do you handle transfers in and out?


Bucknell: Some students end up taking things out of sequence or picking something up at summer school. This has not been a problem.

New College: Dealt with on individual cases.

University of Michigan: Incoming students with Gen Chem start with the "Structure and Reactivity" courses and can complete a program of study in 3 years. Students with Gen Chem and Organic need to pick up the Inorganic courses and the advanced lab, but otherwise just start with P-Chem. Outgoing students do not seem to stay science majors, so we do not have a general reply.

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  1. Do any clients have any problems with this approach (geologists, engineers, etc.)?

    Bucknell: We talk with the biology and engineering departments often and have made accommodations, particularly with respect to the curriculum schedule of the chem engineers.

    University of Michigan: If anything, the reply has been only positive from many quarters. The biologists, especially, like having a more molecular organic course earlier. It allows biochemistry courses to fit into student schedules earlier and more conveniently. The engineers started with more of their students taking "Structure and Reactivity" but the demands of this new subject matter and a laboratory were too much, so they dropped to the "General Principles" course.


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  1. Med/Grad school acceptance rates (before/after)

    Bucknell: We have been offering organic first for over 30 years so an analysis of these rates would be meaningless. We are in the midst of a departmental review and have decided to stick with the program with no major changes. Our students have done very well in locating jobs and being accepted into medical and graduate schools.

    New College: No noticeable change.

    University of Michigan: Hundreds of UM students are accepted to medical, dental, and vet schools every year, and we have always done really well in this regard. If there were a problem, we suspect it would have shown up after 11 years. Similarly, our record of chemistry and biochemistry students going on to top 10 programs was excellent, and this continues.


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  1. Any objective measures of program's success?

    Bucknell: Not really other than the continuing success of our graduates.

    *FYI
    As part of our departmental review, we conducted a student survey to see what they thought of organic first. There was a interesting trend (not really a correlation) that younger students, 1st and 2nd year, remained skeptical but by the time students reached the fourth year, they were converts to the idea. I think the opportunity for expanded electives and research was the main factor in the change of attitude. And they found that, in comparison, organic wasn't really the monster course they all thought it was. Just wait until P-Chem!

    Some in the dept worried about whether we might be losing students who were math lovers by teaching such a non-quantitative course first, that they might be turned away from chem into physics or engineering. I think the majority opinion, however, was that we attracted students anxious to do something "new" in their first chem course, rather than what they might perceive to be a re-hash of high school chem. Also, we think that mathphobic students have an easier time with organic than they would with a typical gen chem course. Finally, we concluded that students that we were losing from organic first would very likely be the same ones we would lose from gen chem first.

    New College: Difficult to say since our transition was gradual. Attrition in the course has dropped to 10— 20% from 40% before.

    University of Michigan: The number of science students who declare science majors and end up going to graduate school has increased. In chemistry, this has been from about 20—25% of students going on for PhDs to 33%. We are highly recruited by industry, and this has improved a bit because of the emphasis on organic chemistry. One obvious change has been a greater number of really outstanding students who declare their major early and who begin undergraduate research as first-year students. Qualitatively, we have received positive feedback from most of our client departments, as well as the honors program and the women in science and engineering program.


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If you have questions regarding the content of these responses, here is the contact information of the respondents:

University of Michigan: Dr. Brian P. Coppola, bcoppola@umich.edu
New College: Paul H. Scudder, scudder@virtu.sar.usf.edu


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